Novel Catalytic Function of MUC1 for the Development of Cancer Therapeutics (TID-242)

This newly discovered function of MUC1 presents a novel target for the development of new cancer therapies and diagnostics.

MUC1 is a membrane bound mucin protein that is overexpressed in 90% of epithelial carcinomas.? Due to its overexpression in a wide variety of tumors, MUC1 is considered an ideal target for the development of new diagnostics and therapeutics.? Researchers at the University of Nebraska Medical Center recently discovered a new function of MUC1.? Research led by Dr. Michael Hollingsworth has identified a ubiquitin interacting motif common to E2-ubiquitin conjugating enzymes within the C-terminal fragment of MUC1.? They have demonstrated that MUC1 is conjugated to ubiquitin via a cysteine residue only in the presence of an E1 enzyme and they have identified potential targets for MUC1-regulated ubiquitylation, such as the transcription factor c-Jun.? The development of inhibitors against this newly discovered E2 active site within MUC1 could become useful therapeutics for the treatment of cancer.? Furthermore new diagnostics can be developed for ubiquitinylated forms of MUC1 and targets of ubiquitinylation of MUC1, which would be extremely useful for cancer prognosis, monitoring cancer progression, and identifying appropriate therapeutic strategies.

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